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I'm using Fedora 33 with Kernel 5.8 on the Dell XPS 7590 now (UHD 630). It seems like they forgot to install the severe eyestrain. Really not bad at all when not looking in a web browser. Needs more testing for overall comfort, however I feel comfortable saying it's better than Linux Mint 20.1 Cinnamon on the same laptop. Although I think I mentioned before that Linux Mint is better on the Skylake desktop I have with Nvidia graphics, and that's still true.
I tried endeavourOS. It was immediately painful on the default Xfce install and the output was very noisy. I think even a normal person might notice all the static.