I just got a series S, and I find it a bit more comfortable because most games can run at 60 fps.
However, even on the old x boxes, some games were unplayable for me. Even in the same game franchise. For example I can play COD MW, but Warzone gives me bad eyestrain. So whatever they change between the two game modes causes eyestrain.
For me at least, the key is running a 720P screen. Anything 1080P or above and I start finding there are more games I can't play.
Basically, the higher the resolution, the more problems. It seems like all the stupid shit they add to the graphics cards or Windows is for the higher resolutions.