Some update - I've pulled the trigger and bought a (used) GTX 1070 graphics card. I figured, since I have a 50-50 chance of getting eye strain, I dont want spend the full price on it, since I dont know if I can use it yet. This was about a week ago. I am installed the GTX 1070 on my home PC, which is a PC that can use without any eye strain whatsoever (before installing the 1070).
Initial findings, unfortunately yes, I do feel some eye strain. I'm still testing and experimenting, for example using analog signal to my monitor instead of digital (hoping it would "flush" whatever it is that is causing eye strain). Since this graphics is installed in my home PC, I can only use it sporadically during weekdays. Will update more after I have managed to use it longer.