To summarize, there are good configurations and bad configurations. A configuration is a sum of factors such as screen's technology, monitor's built in dithering, videocard dithering, OS layer, version of video drivers, the lcd inversion which is present in all lcd's, and probably some other things, too, such as the multiplexer drive technology.
To give an example, I cand use a Zbook G3 (windows 8.1, intel+quadro) connected to a Dell U monitor all day, without issues. When I connect the Dell monitor to the desktop with Geforce 1070, it induces strain. But, with other driver newer than the 2016 one, the Zbook becomes tiring, too. Windows 10 and 11 give the same bad results on this tested good hw configuration.