I'm running the latest Windows 10 build and the latest Nvidia drivers. I am using the Nvidia control panel to reduce the brightness on my Dell 2407 to cut out PWM (not that I've had any real issues with that on this monitor).
The apps I avoid due to causing eye strain are Chrome > V68, and Prepar3D (flight sim) V4. Firefox was bad for a time but seems more useable nowadays. Also F1 2019 under DX12 might cause some strain as well, but I refunded it so cannot test further.