I have the Asus VA24DQ eye care model.
Just bought it a week ago.
It is relatively easy on the eyes when you first use it.
But I still get quite tired/fogged using it for few hours.
After 4 days of using it 4-5hrs a day, I got a headache/fatigue and my eyes gave up.
Then I left a day or 2 to recover.
Overall, I'd still say compared to other IPS monitors I've tried, this is maybe the easiest on the head and eyes relatively.
My laptop screen works far longer for me without strain.
I am going to use the monitor a few hours a day and slowly increase the time to see if I adapt.
I hope to reach a day where I could use it exclusively for 10+ hrs a day.
But I doubt if that will happen.
The desktop monitors for me are just inherently much more straining/fatiguing.