Discovered this recently, I always noticed it but thought it was a fluke, until I actually set aside some time to test it, and found it to be an actual phenomenon...
When I wear my eye patch over my right eye, I can use my Windows 10 PC nearly pain free. However, when I just close my right eye and am not wearing an eyepatch, I experience immediate symptoms, nearly as bad as if I had both eyes open and no patch. But with both eyes open and right eye patched, almost no symptoms
For some odd reason, blocking the right eye with an eyepatch works fine, but blocking the right eye by closing it imparts almost no benefit.
So I tried another experiment, I put on my eyepatch, and looked at the Windows 10 screen, and got almost no symptoms as normal. I then closed my right eye behind the eye patch and the symptoms returned immediately. I opened the eye (still behind the eyepatch) and the symptoms abated a little bit (although once triggered I stay triggered for a while.)
So it seems that on top of knocking out the vision of my right eye, it's state as being open or closed matters.