Most of you already know that even if you have the perfect setup (hardware / operating system etc), web browsers and websites may sometimes still make your eye strain persist. In my case, the biggest issue for my eyes is due to font rendering, which some web browsers insist on doing their own thing.
A workaround for me is once I got a good setup (currently in Ubuntu on a Thinkpad E15 G2, using Tweaks to increase Hinting, change the interface font etc), I installed the Dark Reader browser add-on, in the More tab enable the font and chose (or type) "system-ui". Visually, this looks as if along with changing the font on the websites, it also changes how it's rendered.
This works on both Firefox and Chrome (although it looks better in Firefox) and has improved readability of websites for me, especially those with weird/non-standard fonts. My eyes also find comfort using the dark mode of this extension, but even the Light Mode on Dynamic setting is a lot more relaxing to my eyes than the usual white background. Another option you can tweak on this extension is the Text Stroke, for those who get eye strain with fonts that are too thin.
Obviously, this may not work for everyone, and I haven't tested this on Windows yet, but it would be interesting to know if others find the same relief. You can also change the gfx.font_rendering.ahem_antialias_none (or similar) value in about:config in Firefox to see if that helps you in any way.
Have you found any other workarounds for web browsers that works for you?