Im using those settings:
Their settings is basicly game mode and all image processing turned OFF.
In 2017 it was one of the best 4k HDR TVs. If you set it with rtings settings considering the PWM section in the review it doesnt flicker at all I have tested it with PWM Ufo test.
The strange thing is back with that bad Panasonic I could use it with switch for like 200 hours (Zelda) and then after finished it plugged PS4 and my eyes were bloody red after 20-30mins and headaches.
Then on Sony X900E no bloody eyes on ps4 but headaches... but not when PC is connected to this TV - its fine all that time (except sniper ghost warrior 1 that gave me headache lately but it has bad fov and tearing problems).
You say ps4 pro can make problems cause of HDR well vanilla PS4 has HDR support too.. I have recently borrowed PS4 Slim and have played uncharted demo, re2 demo, ratchet clank, diablo 3 and MGS V. Best was on MGS V this game is locked 60 and no blurrines when rotating camera but played it just for like an hour. Other games well.. I had headaches still so I probably cant play PS4 the normal way 🙁
And yes I have tried it couple years ago with my monitor - EIzo FS2434 and it was fine but playing it that way was not comfy for me. Maybe I will try it again someday but for me consoles is on big screen if I have to play on 24 its pointless I would rather stick to PC then.
And on my old TV KDL-43WD750 I was fine playing all days on PS4... those new things just sux. Im considering also buying 43 monitor but there are only two now LG 43ud79 which uses PWM (same as my panasonic TV) and philips 43 momentum with glare screen which sux hoping new monitors will come.
I have read the forum a little and guys were talking about graphics driver strain maybe thats what is with PS4? My older TV sony the 43wd750 was fhd without HDR I remember after Panasonic 4khdr failed so badly I thought I will go back and buy fhd so i bought 50 inch SOny FHD but this one had HDR so the image processing might be different and it caused me headaches too.
I think it can be related somehow of what you said about how the games on consoles are made - a lot of tricks/lot of blur to make it look smooth with 30fps only and secondly new screens even I have everything turned off some processing must be there or something else. On pc same TV no problems but you can turn off motion blur, screen shake , deph of field, ambient occlusion and I always take 60fps first then higher res/effects.