Hello,
After years of basically impossible to work on any linux desktop for more than a few hours I finally found a linux distro that fixes my eyestrain and does font rendering correctly.
It's an Arch based rolled distro that is very mature called: MANJARO
I run the gnome desktop manager (Aldo i don't like it, it gives me the best font rendering and color combination) with the default settings and it's been great.
Apparently Manjaro changes the Arch Linux font settings to a sort of Freetype2 font and they do it correctly.
Please let me know if you have any questions or what your experiences are.
Cheers