I use regular Arch and currently it is very usable for me, too. I believe we should share our graphics cards, drivers we use, desktop environments, font settings, and any compositing settings.
Graphics Card: NVIDIA Quadro NVS 295
Driver: nouveau + xf86-video-nouveau
Font settings (in Xfce Appearance): Antialiasing on, Antialiasing method: subpixel rendering (RGB ), Hinting slight, no custom DPI
Compositor: Xfce compositor, enabled (in Windows Manager Tweaks), Vsync on
Also look for any existing local or global configuration files that may override or set font settings silently (https://wiki.archlinux.org/index.php/Font_configuration). There may also be .conf files in /etc/X11 and subdirectories that change video output. There may be files in your home directory that tell your graphics driver to use special settings.
The only other thing that I know I did is to try to make sure that temporal dithering is turned off by running an xrender command. But that's specific to the nouveau kernel mode driver and is probably a placebo because it should be turned off by default anyway (https://nouveau.freedesktop.org/wiki/Dithering/).