After a year of back/forth trying to find out why I am getting dizzy when using my computer (beyond a nasty B12 deficiency that has made it harder for my brain to interpret signals like dithered colors)…. I was able to reduce the strain in a few clicks by ensuring my Nvidia card sets the colors vs. Windows. This instantly removed some of the “weird” colors (like black was actually a brighter gray than black).
Here is the guide I used, I hope it helps someone else: https://www.ihse.com/wp-content/uploads/files/whitepapers/ihse-tech-brief-disabling-temporal-dithering.pdf