martin The first thing you should do is to try different Windows builds and check if they make a difference to you. It is possible to download older ISO images of Windows 10 from before build 1607. If that is not an option for whatever reason, then there is no progress in finding the source of the eye strain. It might be the display, it might be Windows 10, it might be graphics drivers. Or maybe even your favorite browser, assuming the browser is the application that is running most of the time. Modern browsers can use all kinds of hardware acceleration and have different methods of font rendering. If you realize older Windows 10 builds help, you might want to get, by any means necessary, a Windows 10 version other than Home that allows you to disable the Windows update service. Or you could still use Windows 7 until it is not supported anymore in 2020. At least with Windows 7, if it is usable for you, you would still get security updates. Windows 10 with disabled update service will get more insecure over time. That is why on my desktop PC I switched to Linux for now, which might not be the best choice for most laptops.