I have been using this monitor for the past 10 days.
Used it with both HDMI 8-bit and DP1.4 10-bit (8bit+FRC).
Use it with 150% scaling.
Display panel used: BOE MV315QUM-N20 (both UN650 and UN880, I've read, use the same panel)
(I've been having some luck with BOE panels, because even the laptop below I use it with has a BOE screen that I can use the whole day without eye strain.)
My laptop spec: Acer Helios 16 Neo - 13700HX, 4060, 2560x1600 16:10 165Hz version.
The display even at first glance, its backlight glow, feels very easy on the eyes (like my dell xps 13 2015 model which I could use for 10+ hrs a day without issue).
I keep the monitor on a 5in table riser, so the my eye level is in line with the middle of the screen.

The first day I had a headache after 3hours or so, but I continued using it for 9hrs that day.
Then on the second day, I used it for again 6+ hrs and this time the headache was much less.
From the 3rd day onwards, had no headache, and eye strain was almost absent or very very mild.
I now use it for 6+hrs everyday with little to no issues.
Brightness (average) I keep around 40 in the day and 20 in the night.
I sit around 2.5ft to 3ft away from the screen.

I have been buying and selling monitors because of headaches/eye-strain for the past 5 years, and this one is the best one so far by a long shot.

The monitors I previously tried:
-- LG 27UK650 IPS
-- Samsung SR350 IPS
-- LG 32GK650 VA
-- Asus VA24DQ/VA24EHE Eye care
(this was the easiest to use in this list, but still gave me a mild headache if I used it for more than a few hours)

So, I finally got my dream satisfied, of a 32" 4k monitor that I can use for an entire day without headache/eye-strain (just very little of it if I push the brightness too much, sit too close for long, or use it continuously for too many straight hrs).

The 32un650/un880 has a wide-color gamut, so colors look nearly as good as my phone's OLED screen.
It also has 5Wx2 speakers that sound quite good.

The only issue I have with the monitor is in the panel lottery part - I got some mild color uniformity issues, the left side is more yellowish and the right side is more reddish, but it is very mild and I see that only in a full white screen + focus on that).

    Deepak I now use it for 6+hrs everyday with little to no issues.

    what about win version and laptop's screen - can you use it?

      simplex
      Yea laptop screen is fine too (2560x1600 16" 16:10 500nits BOE NE160QDM-NY1 V8.4),
      Can use it for the entire day with no issues.
      The laptop screen also gave me mild headaches for first few days, then it became comfortable after that in the following days.
      This is on Windows 10.
      Have not tried Windows 11 yet.

        Deepak This is on Windows 10.

        can you type winver in search bar to get full win10 build number?

        are you using windows hybrid mode ( nvidia and iGPU ) or solo nvidia…?

          simplex
          Windows 10 Version: 22H2 (OS Build 19045.4170)
          Using only dedicated GPU 4060 (changed the MUX switch in BIOS).

            6 days later

            Which is very interesting, because to me all BOE panels I've tried immediately caused nausea, as they have grainy coating and aggresive backlight to my eyes. OTOH Innolux and some AUO panels do not cause these problems. LG depends on particular panel, but harsher than Innolux for sure. Sadly Innloux often have low contrast, below 1000:1.

              VSABALAIEV78 I would advise to be careful with BOE panel based screens, as none of them have shifted bluelight peak (high phototoxicity) , which means they might be comfortable for someone eyes (not for my) , but unhealthy nonetheless. I mean I get that, if the only thing that works for you is BOE, then yeah use it, but before try Eyesafe and TUV Hardware Low Blue light certified panels, and make sure none of the fit you.

                You can try the Reading mode in monitor settings to reduce the blue light. In this case, the screen feels like a paper. + use scaled resolution x2 (1080p)

                  VSABALAIEV78 Well, unfortunately using reading mode neither provides good protection against high energy blue light, as the blue light peak still stays in high energy zone (450 nm instead of 460 or at least 455 nm) nor it maintains good color. I mean, yes it is better tha nothing, but Eyesafe monitor during normal operation has same amount of harm, as a regular one in "Low blue light" mode, and in Low Blue Light mode, an Eyesafe device will have almost zero harm (related to blue light).

                    EyeDiscomfortCertificate
                    Which monitor models have "Eyesafe" or "TUV Hardware Low Blue light"? - just to name a few?
                    I see that on some Asus models, but I had headaches from the previous monitor I had tried - Asus VA24DQ/VA24EHE.

                      Deepak Which monitor models have "Eyesafe" or "TUV Hardware Low Blue light"? - just to name a few?

                      my laptop screen is "TüV low blue light" but causes headache %)

                      EyeDiscomfortCertificate an Eyesafe device will have almost zero harm (related to blue light)

                      sometimes the advantage in blue light peak shift is not worth it though, as these monitors can still have really peaky backlights and just harsh feeling light emissions in general.

                      FWIW i seem to literally have less strain using monitors that look generally colder to the eye (but not TOO cold)

                      yellowish/greenish tint = strain for me

                      14 days later

                      EyeDiscomfortCertificate I have the same experience with BOE. In the store though I looked at Lenovo Ideapad 5 Pro 16ARP8 with this panel: NE160QDM-NY2. It seemed comfortable on the eyes, HOWEVER, it can be deceptive qs I was using it like for 5 min only. I may actually return to it and give a try at home. one last chance for BOE)) The panel actually has the latest EyeSafe cert plus low-blue light (as per Lenovo site > Specifications > Display), but like someone said above it means nothing in terms of actual eye strain in most cases.

                      a month later
                      20 days later
                      dev