jpark28 I received it and set it up yesterday, and felt symptoms within minutes. I thought this was insane as it's the same monitor from work, so I tried to push through and the symptoms got worse.
This is totally possible for a couple reasons:
Monitor manufacturer may have changed where they source the panel from over time, or the panel manufacturer chose to update their specifications indepedendently. If this one is the case, maybe buy the monitor used (instead of refurbished) from someone and asking them to check the date of manufacture on the sticker on the back of the monitor, with the goal of trying to find something that lines up a similar date of manufacture to what your work monitor says on the back. But you still might run into the second issue below…
Monitor manufacturer may source panels from various sources at random. The infamous "panel lottery", which is VERY common. Recently I saw a grid of 16 ASUS 4K monitors for signage all displaying one image together and EVERY SINGLE ONE had a different color tint, white point, brightness, level of "glow" to the screen, sharpness, level of "harshness" to the backlight, and even percieved "comfort level" for me looking up close at each one. It was obvious even from a distance which was really funny to me.
Refurbished monitors can definitely end up replacing the panel with either a generic part or an official part that ends up being sourced from a different manufacturer. Buying the monitor new isn't always a solution to this either, though, because of the above two issues. In the end what you get is pretty much based on luck.
Sometimes you can see which panel a monitor uses by entering it's service menu or factory menu, you usually can find a known "secret" button combination to enter these menus per each manufacturer online.
Good to know that you're using the same laptop, as that means the possible reasons can be narrowed down. Otherwise, which computer is connected can definitely be affecting the video signal, so using the same laptop definitely helps prevent that (in most cases). Are you using the same cable at work and home? Bandwidth might affect which video and timing mode or the laptop chooses to select as well.
Just to note, AMD graphics cards have been known to generate temporally dithered noisy video signals since the mid-2000s. Modern (RTX and later) NVIDIA cards have been caught by others here to be doing it too. M1 and later Macs also output noisy signals by default (but unlike the other GPUs, it can be much more easily disabled on M1+ GPUs in external output with the Stillcolor app).
Finally, even though the monitor panel being different is totally possible and common, there are some cases where it ends up not being the montor and instead the lighting conditions in your room. I don't know whether the lighting at your workplace is natural sunlight or LED/flouresecent, and if it's artificial, how much it flickers every second and what it's CRI and color temperature is etc… any of those can be different in your home and definitely can affect screen comfort.
Using your monitor at home with all the lights off can help narrow down if it's the lights or your screen.