Years ago I switched from Ubuntu to KDE Neon. I haven't tested a whole bunch of distros, but KDE Neon was an improvement, and I continue to like it. A while ago someone here said KDE is the best desktop environment for their eyes, with GNOME coming in last. He placed Cinnamon second. I've seen many say Linux Mint (usually Cinnamon) is fine for their eyes. Also Manjaro KDE has typically scored better than other options.
I like KDE Neon because it it uses the familiar Ubuntu base. Linux Mint of course also builds on Ubuntu. With KDE Neon you can choose between X11 and Wayland while with Mint you must use X11 now and for some more years. Linux Mint also disables snaps. Not a big deal, but I kind of snap functionality since a few of my key programs have officially verified and maintained snaps.
I haven't tested the eye health differences between Linux Mint Cinnamon and KDE Neon, but maybe I should. In terms of which DE is better for daily usage, I would think KDE Plasma 6 is significantly better than anything else.
As always, I am interested in reading the experiences and observations of others.
The ones most of interest to me are Manjaro KDE and Linux Mint Cinnamon because these are the ones most likely to alleviate eye strain complaints based on what I've read.
Also interested in any anecdotes from others regarding KDE Neon.