technicalitch
Even in fullscreen, the video did not give me any eye strain on my safe laptop setup -- ThinkPad T480 + custom installed AUO B140RTN03.0 TN panel (100% backlight) + Basic Display Driver + ditherig.exe.
If it matters I'm also using Windows 1809 and Firefox ESR 115.12.0.
However, given the really up close perspectives of things and the shutter issue WhisperingWind noticed, as well as the higher than usual "oversharpening"/high-contrast edges type of effect I can see in the video, I can definitely see how this will cause strain with a bad monitor (or bad GPU postprocessing). My setup isn't affected by it though!
In addition, because I'm using Basic Display Driver I sometimes get a "tearing" effect similar to the shutter issue even when just scrolling or watching other videos, but even in those cases the tearing actually doesn't bother me at all on this panel. (Tearing does irritate me on strainy panels though)