For me using Windows 11 is a relief compared to my Macbook Air M1 or iPhone. It is so sad to read that your setup gives you pain.
I'll give you my setup if it can help you or others: Windows 11 + RX570 + screen HP E24i G4 with brightness at 9%. I didn't configure anything else related to image processing. Windows & drivers are up to date.
For Mac users: StillColor helps (a lot) but the Macbook M1 still gives way more fatigue than previous intel macs I have which are really painless (but too slow & deprecated).