Donux
There are some fantastic posts by the mod of r/Temporal_Noise going in-depth to the different types of dithering. Recently he utilIzed the new program shared by a user here and on that sub on disabling HDR on Android phones. He has several threads showing the results: https://www.reddit.com/r/Temporal_Noise/s/P7WLVh77gl
From what I understand, different refresh rates resulted in different dithering techniques: temporal dither and FRC. Depending on the setting it introduced more or less frames, and was therefore more or less uncomfortable. I’d recommend reading his posts because he’s doing great work.
So to your question, in theory, yes. But it depends on the frequency and the type as well as when it is engaged.
In actuality it seems like dithering is not being used to increase comfort but rather to extend battery life and make 8-bit screens look flashy. A cost saving measure driven by shareholders and the marketing department. If this were actually a good thing, we wouldn’t be seeing an influx of users since the M4 MacBooks were introduced. But we are.
There definitely are consequences to disabling dithering on devices like the new M4 MBA models that very clearly rely on the technique in a fundamental way. I think Sequoia is the worst offender as of late. The MacBook Pros are probably much more complicated because the dithering noise interacts with PWM.
DisableUniformity2D on Stillcolor seems to make the new Airs even worse. It breaks something in the way the display functions and you can see and feel it. Intel Macs probably are benefited more by disabling dithering than newer ones. I think MacOS Sequoia is heavily dependent on dithering and I’m not sure it’s usable for most of us. But we would need an analysis to truly see that.