For the Mac mini 2018 paired with the BenQ BL2420PT monitor (IPS, 6-bit+FRC), I find the 10-bit output setting (versus 8-bit) produces the most visually comfortable image.
The separate Windows 10 22H2 PC (Intel UHD 730) only outputs 8-bit to this monitor, yet the image looks as comfortable as 10-bit on the Mac.
A Mystery: To the naked eye, it's puzzling why the Mac mini's video subsystem behaves this way compared to the Windows PC and my M1 MacBook Pro. When I have time, I plan to analyze the HDMI output with a recorder to get concrete data on what's happening.
AshX
I bought a MacBook Pro 16" M1 Max with a MiniLED display a year ago. It was extremely uncomfortable to use with my external BenQ GL2450 monitor. Although the MacBook Pro M1 was very comfortable with the same monitor. I sold the MacBook Pro 16" M1 Max.
The only thing that made it OK was the option to stream the content of the virtual display in BetterDisplay to the physical BenQ GL2450 display. But the performance in this case wasn't great.
I tried it on several operating systems, including Sonoma. When comparing it with the MacBook Pro M1, I always brought both MacBooks to the same OS and firmware version via DFU.
P.S. Additional Note on the BenQ BL2420PT: although this monitor is advertised as PWM-free, it has a different kind of signal spike that can also cause eye strain during long sessions.