Something totally unexpected has just happened. I may have made linux usable somehow. What I did:
- disabled dGPU (RTX 5070) from BIOS;
- switched to intel i915 driver;
- disabled dithering by writing to GPU register `0x70008` using `intel_reg` from `intel-gpu-tools`
- installed Wayland's Sway component for GUI with foot terminal;
- disable keyboard backlighting.
I've spent the last 2 hours testing and experimenting with this setup -- and got no eyestrain. This is actually the first time every i'm able to use a linux distro with no strain. It has always been the most aggressive environment for me causing neuro symptoms very fast with any desktop or even barebone X server. Take a look at the screenshot:

Fully functional. I haven't installed a desktop environment (DE) yet -- but frankly who needs it when everything's working from terminal including any GUI app?
What's most surprising? I'm running it on a completely unusable (otherwise) notebook! Honor MagicBook with Intel Core Ultra 9 285H (Arrow Lake). It's a top-notch mobile processor. It caused massive pain on ALL Windows (Windows 10 1809 and higher, Windows 11 3 or 4 different builds), on standard linux DE setups.
I'll be testing in the next few weeks to confirm. If my condition holds stable, this is a massive breakthru. Let's see.
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Some info about the display after LLM examination:
Your display reports as a 10-bit panel (10 bits per color channel = 30-bit color total).
Panel: TL160MDMP01
Advertised: 10-bit per channel
Interface: DisplayPort
However - and this is important:
Many panels that advertise 10-bit actually achieve it through FRC (Frame Rate Control), which is temporal dithering.
The fact that disabling dithering (register 0x70008) massively helped your eyes strongly suggests this is a 6-bit or 8-bit panel using FRC/dithering to fake 10-bit.