martin
It might be hard to test - since I don't use this Mac on a daily basis I got a little bit immune to this screen, at least on W10, ie. when I used it a lot even 5 minutes could trigger issues, now I can stand 1-2 hours, this doesn't seem to cause long time effects (broken sight for one day, etc.). It was a surprise when I started doing these tests, rendering videos, etc. Maybe it's new W10 which is somehow better than older updates.
So I think it would probably tire my eyes faster by looking through the scope, in a physical way. It's a single lens microscope, so different view in each eye could be problematic too.
Anyway, do you want to check if issues start to appear due to light coming from the screen, not the focusing on it? Maybe running this notebook as a background "lamp" on a flickering shade and trying to see if I get tired eyes without looking at the screen directly after 30 minutes would be a good test then.