deepflame I don't know what to use anymore when directly connected to a display. No matter what, there's always that small Linux eye strain that accumulates over time. That's why I use VNC. That way whatever would cause the eye strain on a directly connected display won't happen. Provided the VNC client itself is OK to look at.
Maybe there are hardware/software combinations that work nowadays, but I don't feel like buying new graphics cards which require new PC components over and over again anymore just to find out it was expensive but didn't help.
I remember on Ubuntu Mate it helped to turn off the desktop composition. But it just helped, it didn't fix the eye strain.
I think running a trusty old machine (could be even Windows XP or earlier) and then connecting via VNC to a new PC is an option - if you don't need multimedia.