I've never tried an AMD GPU but based on testimonies here I wouldn't hold your breath.
Another thing to consider is that this will need to run Windows 10/Linux and ideally the latest drivers for best performance. This is when we get to that grey area again of is it the GPU/Drivers or OS causing issues?
OTOH if you can find one from a retailer with a comfortable returns policy (Amazon), it may be worth a shot. My 8th gen NUC isn't being used right now, though. It's a real shame as these mini PC's such as NUCs are so much smaller/quieter than the decade-old SSF desktops, and more than powerful enough for modern computing needs. I may look into a remote desktop setup soon so it doesn't keep gathering dust.