This evening I decided to go through all my adapters and video ports to see which might be better.. this was primarily motivated by the fact that Amazon Prime Video for movies enforces HDCP when I normally use VGA, though it doesn't enforce it for TV shows which is inconsistent, but appreciated.
There are two settings in the Intel drivers which will affect how stuff is rendered.
IT Content (Display>General Settings>Advanced) - For movies, etc. this setting should be off but is on by default. What it's for, when set to on, the drivers will try to "sharpen" text more than whatever you've set in the display itself. I feel that having it on will interfere with the picture quality in videos and if you have already correctly set the panel's sharpness, why even use this setting at all? This is a subtle setting, but it does have an effect. Have it off, just like all the settings in the Video section of the driver control panel which should also be off.
YCbCr (Display>Color Settings>Advanced) - HDMI connection is required for this--DVI and VGA are natively RGB. Generally better for movies due to how they are mastered, but less so for text although the difference is very small if your display panel is already set for a 4:4:4 chroma mode. However, here is the interesting thing about this setting.. if this setting is on (when off, the mode is RGB) the Intel GPU in the computer does not decode the image to RGB, instead the monitor itself does the decoding to RGB then displays it. Where this may come in helpful is if the GPU is problematic (especially in light of all the discussion we've had about dithering) it might worth experimenting to see if it helps to have the decoding done by the display panel instead due to some here saying they have known good displays that go bad when connected to certain setups.