I have tried two laptops now (HP Omen 15 and Lenovo Legion 5) with a MUX switch, allowing me to theoretically switch between the output of the Intel integrated (Hybrid mode) and Nvidia graphics (Discrete mode) on both laptops.
I have found that in this small sample size, Nvidia graphics is worse for me than Intel. I rapidly get migraine symptoms with eye drooping on Discrete mode, which feels distinct to and is significantly worse than my usual OS-related discomfort.
In my case, modern Nvidia notebook adapters are modulating the display output in a way that produces a severe negative reaction.
More subjectively, I find the output of the Nvidia adapter to be cleaner looking and more still, which, based on my symptoms, is the opposite I expected.