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It took me 3-4 weeks for the pain of adjusting to new lenses to stop. I noticed the 60-70% relief from flicker symptoms pretty quickly, within a few days IIRC. It definitely took a long time to actually adjust to the lenses though, and I'm not even sure I'm 100% there yet. My advice would be to pick the pair that you think provides the most symptom relief, and then wear those exclusively for a few weeks. In my experience, prism lenses do demand quite a bit of time to adjust, but I hope you'll see improvement as you wear them