tonyhawk99
Thank you for G Sync recommendation. Turning on AMD FreeSync on my monitors and enabling G Sync in NVIDIA Control panel resolved the eye strain issue that I started having after upgrading my PC. It got so bad that I could feel myself running from using PC that I painstakingly assembled for gaming. Now I can use it for hours without problems again.
I think the issue might have something to do with Vertical Band locking that someone mentioned here. I imagine FreeSync/G Sync overrides it.
More details about my case:
Monitors (Stayed the same): Tesla 24MC625BF through DP, those are simple 1080p 60-75Hz "flicker-free" IPS monitors.
Old GPU (no problems): ASUS ROG STRIX GTX 1060 6GB + NVIDIA 532 Drivers + Win10 22H2
New GPU (eye strain): GIGABYTE RTX 4070 TI SUPER + NVIDIA 566.36 Drivers + same Win10 22H2
Note: I had to do clean reinstall of NVIDIA drivers because 532 apparently did not support my new GPU fully.
Symptoms: eye strain, eye redness in the evening (mostly recovers overnight), drowsiness.
What helped: Turning AMD FreeSync on monitors and enabling G-Sync in NVIDIA Control panel.
What did not help: forcing no dithering with novideo sRGB (it was already disabled when I first opened this utility), playing with desktop colors in NCP, setting Nvidia profile exactly as it was on my old PC (through Profile Inspector export - import), setting output dynamic range from full to limited, Output Color Depth adjustment was always unavailable for me (=8 bpc), trying iGPU with reduced "color intensity": the symptoms just turned into headache after ~3 hours with it, changing output cables from DP to HDMI.
Other general methods I use to reduce eye strain: sitting 110cm away from 24" monitor: I can sit closer but I would get eyestrain after couple hours with any monitor and settings, even "good" ones, blue at 0 in monitor OSD settings, f.lux general use 1900K, gaming & movies 2700K, placing PC outside of direct sunshine, semi-transparent drapes to reduce glare, when I had eye infection, I have also used yellow "rainy" driving glasses that help take extra edge off from bright-themed applications and web-pages.
I have had similar issues before when I was upgrading from Win7 to Win10. First time I tried it, my eyes hurt so bad that I abandoned it for another two years. I think it did not even have dark theme at the time, or I couldn't figure how to enable it. Next time I have tried upgrading, it was much better and I got away with reducing blue and digital vibrance in NCP.
Thanks again for all the advice in this forum!