I have followed the instructions from @NewDwarf on how to disable dithering on my M1 mac. I didn't see much of an alleviation of symptoms. I have also reduced my resolution to 1600x900 using BetterDisplay, again with not much of an effect on my symptoms.
Specs:


Interestingly, on my other Mac, I don't use BetterDisplay, but did follow @NewDwarf instructions to disable dithering, which helped me greatly. I can use this Mac, with pretty much no symptoms.
Specs:


Just a note that on both Macs, I am using external LCD TFT backlit monitors.
I wonder if it is because the usable on is running Big Sur. And the unusable one is running Monterey?