Hi just an update, I do not see any better solution than lowest grade possible colour profile. This app really has no affect for me at all. If this is temporal dithering, then for sure if you select lowest colour grade, there will be no need to emulate colours for lower grade display, and I'm pretty sure bellow colour profile:
Has lowest spectrum coverage, and also, it is less bright - making PWM flicker less intensive as contrast is higher.
And those ideas that suggest to turn off "True Tone" are also a bit absurd to be honest, since there is no way this could have negative affect on eyes, only positive.