color profile (.icc) almost do nothing on reducing eyestrain. Color profile can only adjust color to be more natural. The standard sRGB profile is enough (or AdobeRGB if your display support that many), so no need to change, just keep it default.
And, color temperature (f.lux), or called white point, won't make any effect to eyestrain at all. It only makes screen more yellowish or bluish. So no need to change, just keep it default.
(Is what I said correct? 😄 )
Another tip, stay away from Electro Dance Music (EDM), or some kind of strong sense music (or high frequent vibrating music), because they can hurt your Centural Nervous System in your brain, to make you impatient, and much more sensitive to colors & sounds. So don't listen to them any longer to try to keep calm.