I just want to share my possible solution for the eyestrain on M1 MacBook pro 16. I’ve been using MacBook Pro 2015, 2017, 2019 and 2021 for the past few years. I get no fatigue or eyestrain on 2015 model. But I am severely affected by 2017, 2019 and 2021 MacBooks. M1 MBP is the worst among all these models, I get eyestrain within 2 minutes and it lasts at least for the whole day. For the M1 model, I tested all kinds of the possible suggestions including disable True Tone, promotion, select srgb profile, turn off font smoothing, adjust brightness, etc. None of them works for me, it’s just like the whole screen is waving or shaking which makes me extremely hard to focus.
Then I tried a color profile called PAL & SECAM Video(BT.601 EBU). Once I switch to the profile, I instantly notice the screen become static and I can easily focus, read the text just like I’m using mbp 2015. Although it does not 100% solve the problem, I can look at the screen the whole day with a little fatigue. With the profile, I also tested the above settings and there’s no problem for me.
If you didn’t try this color profile, I hope it works for you.