I received the LG 27MQ450-B from @GregAtkinson last weekend, and I set it up as my main monitor at work to give it a thorough test. Around the same time I also received the Opple Light Master 4 I had ordered, which I know has limited capabilities, but I thought it would at least provide an empirical measurement along with my subjective perceptions.
Leaving the display settings as they came (Brightness=100, Contrast=40), my very first impression was that the picture appeared somewhat unstable. I had a slight perception of the picture moving or flickering. I took a few readings of a white background with the Light Master, and all readings were something like this (I calculate 12.6% flicker using (max-min)/max):

I ultimately reset the brightness and contrast settings to their defaults (I believe ~75 for both), and the picture looked brighter and more stable, although still not as stable as my old Dell monitor from 2013. I initially thought this might be usable once I got accustomed to it. I took another Light Master reading of a white background, and got this (I calculate 7% flicker using (max-min)/max):

I then tried reading emails on the screen for an hour or so (my typical use pattern). Unfortunately, I got the symptoms I get with most modern displays: focus problems, blinking constantly, a feeling like a flashlight is shining in my eyes, lack of comprehension, etc. I forced myself to use it for a few days, and perhaps adapted to it slightly but not significantly.
I am open to thoughts on this, because this sounds contradictory to GregAtkinson's testing indicating very low flicker. My initial thought was that the AC power in my office may not be very clean, or that there could have been a GPU output issue (however, none of these changed from my old setup, which was perfectly comfortable). I was connected via DisplayPort, just like previously (well, previously it was a DisplayPort to DVI adapter), so I wonder if I should try a different cable or try connecting via HDMI. I also am a novice user of the Light Master device, but the measurements do seem to correspond to my real-world discomfort.
For reference, this was a Light Master reading of my old Dell monitor from 2013, which I found perfectly comfortable (the PWM is quite evident, but I can use this all day long):
