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tomek Thanks for your response. I have seen your post and tried your settings a few days ago, but unfortunately they did not make a big difference for me. Yes it is a bit easier on the eyes, but I still get this very weird dizzy feeling, pain in my eyes, can't focus on the screen etc. Distance also doesn't matter. I can watch a Samsung Neo Qled in vivid mode and full brightness in the store and don't get this weird sensation at all. Yes I get a bit fatigue from the very vivid brightness, but that feels very different, I would say more burned feeling. If I try your settings the picture also becomes too dark for my personal taste. I am pretty certain for me it is not so much a brightness/blue light or contrast problem, but more a motion/flicker problem. I can't even watch this tv for more than a few minutes a day. I will give it a few days rest and try again. BTW I also tried a Sony Bravia 8, which actually has a much more natural and less colorful tuning.
The fact that I am already experiencing it when the screen is still/pauzed makes me think it is the brightness dip (flicker) that happens with every refresh cycle on Oled tv's. You can clearly see it when you make a slowmotion 240fps video on your phone. Somehow I don't seem to be sensitive to PWM flicker. For me changing to a miniled is probably the best thing. Oled's unfortunately are not for me. Maybe in the future when Oleds are replaced with microleds, I can test if it is indeed the contrast or the refresh tech.
Update 08/08/24: I went to the optician today and found out I need prism glasses due to double vision, see more detailed response below.