As a person who's been still using a CRT (Samsung SyncMaster 795mb) at home for the majority of tasks, I'd say it depends on the model of a CRT monitor, as well on its settings and especially on the refresh rate.
1. I don't know why, but I've always had quite bad experience with LG (Especially those of LG's called Studioworks, probably of their lower refresh rates), but who knows, may be it's just a pecularity of my perception.
2. In the beginning, I tried to set my monitor's brightness according to the instruction manual - to the level when the most dark shadows of the image just slightly appear, and it always caused a lot of eye strain. Then my dad gave me advice of setting contrast to 100% and brightness to 0 and it worked! (In spite of losing a big part of shadows, the image appeared very easy to my eyes, and I'm still using such settings, though they're not good for photo editing for example)
3. As for the refresh rate, I prefer working in 1024*768@ 100 Hz mode so flickering is almost unnoticeable.
Unfortunately all the CRT monitors are at least 15 years old at present time, so their condition varies. As for me, I had to repair my monitor myself - replaced HOT as well as a faulty diode in puncushion correction circuit.