WhisperingWind I can use Windows 10 22H2 with no issues, provided I ensure it's running in 8-bit RGB full, and no dithering is present. It is my main, safe build. My work laptop is also Windows 10 22H2 and also, no issues.
I've tried MANY builds of Windows 11, using two 'known good' monitors, and others, three different graphics cards at at least three different laptops. ALL of them are very uncomfortable use except the very first build of Windows 11.
Microsoft broke something very very badly.