Just a thought on this one, I've had a bit of a headache for a couple of days so havent been able to do much tinkering with settings etc but I think for me grey filters seem to help and I'm looking at ways of imitating 'reduce white point' that IOS has....that seems to 'draw' a grey filter over the screen to make the whites less bright. Reuducing brightness without reduce white point does not have the same effect - at least with me.
Previoulsy I would get migraines outdoors if I didnt wear sunglasses and used to wear polarised sunglasses almost constantly (I've stopped now)
so theres something there with filters. If my headache clears up I'll try looking at some patter glare tests with various levels of reduce white point.
Otherwise my other thought was about colour blindness, if someone can be 'slightly' clourblind, not fully as in Red looks like Grey etc, but what if the Red (etc) that I see is not the same as the Red (etc) that someone else who doesnt have problems with screens etc sees....