More recently than when I started this thread I have been running my Nvidia Quadro K4000 on my desktop instead of the Intel GPU or GTX 650 Ti Boost. I haven't done enough A/B testing comparing to the other adapters but I've been tolerating it. I've switched to the viewpoint that with my graphics adapters in a pretty good place, good panels, tolerable OS, that most of my strain is coming from software sources now. Web browers which is well known now and others which were mentioned recently like Office and pdf readers.
Was accessing the website versions of Office on Pale Moon last night and that seemed more tolerable than the desktop application. Pale Moon is still my most comfortable browser (sometimes I think Waterfox Classic is OK, but I'm not sure. Pale Moon is better. Basilisk is another one I've been meaning to try).