I tried all the color profiles on my 2015 13 MBP and it made no difference, tried different operating systems as well and no difference. Not sure what panel it had but I sold it as after nearly 2 years it was unusable.
Anyway as we're all different I throw my 2c in, I have 6+2bit LG IPS and its fine to use as is a 8bit Benq TN on my good hardware, can and do use them all day. Bad hardware makes them both unusable to me though. But also so do two games I've tried recently, they will cause me a migraine on otherwise perfectly usable hardware for everything else.
Even on laptops that are good for me on W10 I've installed a different OS (ubuntu 18 / 20 etc) and these are bad. Same screen same everything just different OS will cause them to give me a migraine. I could see the purple ubuntu screen shimmering when I last tried it and then minutes in a web browser (firefox) and the damage was done. Migraine.
Also recently I've got a large iiyama IPS and I cant use it, its flicker free but I think its also 6+2 bit but it gives me a migraine.
Seems to be some things are good and some bad, but bad hardware will make a good screen bad, but a bad screen may always be bad.