ensete I find it interesting that there are definite camps in iPhone land. There are those who could tolerate anything up to the iPhone 4s and iPad 2... and find the iPad 3 and iPhone 5 to be uncomfortable and the iPad 4 and iPhone 6 to be downright excruciating... that's the group I fall into. But there are others such as yourself for whom even the iPad 2 (and presumably iPhone 4/4s because it's the same display tech) were problematic.
My suspicion? I'm not actually sensitive to Retina displays in particular but in SOMETHING they started doing with CERTAIN retina displays. The fact that I can use my GF's iPhone 7+ for brief periods with NO brightness modulation and NO blue-light reduction and NO matte protector, and that I can use my buddy's iPhone 7+ with a matte protector for long enough to fiddle with an app, take a picture... means that these displays are all very different.