From my new company, I have got MacBook Pro M1 2021 16 inch 32GB laptop for work. With default display settings, I could not use the laptop for even 30 minutes. I started playing around the display settings and found a 90% working solution which is able to work 3-4 hours straight which is more than enough for my work.
My 90% working Settings for the Built-In liquid Retina:
Presets : Internet & Web (sRGB), refresh Rate: 47.95 Hertz.
Settings for external Benq monitors:
Persets: sRGB IEC61966-2.1 Refresh rate: 60 Hz
The default settings of the laptop is Presets: Apple XDR display (P3-1600 nits) and refresh rate : Promotion. This setting is absolutely unbearable for me. Within 30 minutes of laptop usage, I encounters symtoms like neck pain, weird chest pain, little elevated heart beats, Pain over shoulders, headaches & feeling weight on my eyes, difficult to getting sleeps on night, difficult to think during speech (sometimes I stuck what I have to speak next in meeting, kind of brain fog)etc. Thankfully I have found some settings which is bearable. Otherwise my technologist career might have come to an end.
With all these experiences, I assume this LED strain is related to colour spectrum. Usually Blue colour is only hyped as evil. But in my opinion every colour at certain extended frequencies causes strain on human eyes. Companies need to do more research on this.