I'm a long term sufferer of extreme migraines and headaches which started after purchasing my Macbook back in 2011. I'm a long term reader and contributor of this and the Apple discussion on the subject.
After many years of trying to find solutions to allow me to use a Macbook, I have discovered that I have a particular sensitivity to temporal dithering algorithms used by OSX, some monitors / TVs and AMD graphics cards on PCs. After countless trips to doctors, optometrists and specialists there's nothing noticable wrong with my eyes, and various forms of glasses did nothing. I have only persisted with trying to use Macbooks as I teach people who use them for a living.
Anyway, I took the plunge three weeks ago after lots of tests in stores and bought a Dell XPS 15 9550 laptop (1920x1080 Matt screen, Nvidia GTX 960M & Intel 530 graphics). As soon as I received the laptop I installed Ditherig.exe:
This disabled temporal dithering for Intel graphics cards. Three weeks in and my headaches and migraines have lifted. I can use the screen for hours on end with no problems whatsoever, it's back like the old days when I had a laptop without an LED display.
I do feel that the exposure to Macbook screens over the years has permanently affected my eyes though. I find that if I'm even slightly tired and I look at any kind of screen with LED lighting I'm likely to wake up with a headache or migraine, which I believe is down to s sensitivity to blue light which has increased since my problems began.
Anyway, I'm happy with where I'm at just now and wanted to share my news in the hope that it might help someone else.