simplex
Is Windows 10 1809 LTSC (build 17763.1098) with WDDM 2.5 better for you than Windows 10 LTSC 2021 (21H2)? What kind of symptoms do you get on 21H2 WDDM 2.7?
Why did you reset CMOS and reinstall the drivers? I feel like testing should be done without reinstalling the driver.
Have you tried any other GTX 10xx cards besides ASUS? If so, which ones, and how did your eyes react to them?