I'm new to the forum, and wanted to say I concur. It's absolutely multifaceted. I went into my eye doctor complaining about neck and shoulder pain, dry eyes, tired eyes, hard to maintain eye contact with people close to me, eyes hurting during work hours, and all the rest. He had a machine to do testing and suggested rather eye therapy, or contoured prisms ("Neurolens"). I took the glasses approach, and have experienced immense relief. This is anecdotal, but if anybody here has tried literally everything else, consider giving the Neurolens a shot. Worse case scenario, you return them and get your money back. Eye therapy is also effective, though I haven't tried that.
In terms of monitors, I recently got some curved anti-flicker VA panels, and set them further back on my desk, and it's been wonderful. Sure, they have less color, but the lack of punchy colors and vividness has been nice. In addition to the neurolens, although I haven't been cured by any means, the eye strain/pain has rarely been something I think about. It's there, as I notice once or twice in a week, but most of the time it's barely an inconvenience.