- Edited
I am currently running Debian 8.2. Trying if I get used to the (small) eyestrain I always have under Linux.
I use proprietary NVIDIA drivers with dithering disabled. Well I hope it is really disabled.
So far I feel no difference between font antialiasing off and on. But in VESA text mode (no KMS), there is no eye strain at all. Disabling hardware acceleration in xorg.conf (Accel false and NoAccel true) did not help.
There is no Linux eyestrain from within Windows (10), be it a virtual machine or a VNC remote connection. Which makes me think the problem is something only a physically connected monitor can show. A driver problem, something open and closed source drivers have in common - or an Xorg problem.
If you have Linux eyestrain, too, let's try to isolate the problem. All major desktop environments should be able to disable font antialiasing (sometimes called "smoothing").
I noticed that Linux uses different video modes than Windows. You can recognize this when you use a VGA connection, factory reset the monitor and then first run Windows, then Linux (same resolution and refresh rate). The monitor will have to auto-adjust, telling me that the Linux mode is a new mode that has not been saved before, and that something is different even though it says 1080p@60Hz in both examples.