- Edited
Currently on a Xubuntu 16.04 on a struggling 2006 Toshiba Satellite with a CCFL display without eyestrain because I have not found anything to upgrade to without symptoms. Used 14.04 and several previous Mint versions in the past without problem.
I have found no "modern"/LED backlit device that any of those or any other distro/DE/OS is comfortable on since this problem began for me 2+ years ago. I have tried every tip posted including editing config files for driver settings etc that others swore solved their problem. Nothing ever helped. It was first noticed when I used a Lenovo Ideapad for a few weeks live booting Solus/Budgie. Prior to that I was using the Toshiba primarily. In 2017/18 I did extensive testing with an Thinkpad X1 Carbon 3 (Intel HD 5500) off eBay and the default LED/TN display was painful on any distro even in the BIOS/TTY. I tried 5 different panels in it (no PWM/color profiles etc) to no effect. Same story with an X1 Carbon 2 (Intel HD 4400) I tried and returned a few new devices of all price ranges from Best Buy with Intel and AMD of various combos including Ryzen only laptops. I have not had a desktop since this began so cannot speak to various GPUs/displays/connections.
The only LED backlit devices I used comfortably before this began were 2009 and 2011 Macbook Pros with OSX Lion/Mountain Lion and those had LED/TN displays (one glossy/one matte) which I sold before this problem (however trying a used 2011, ostensibily with the same display and specs, on the current MacOS in a store was immediately miserable) , iPad 2 that is maxed out as iOS 9 and still doesn't hurt, and a Nokia Lumia 635 Windows Phone. I have a Moto G4 Play with Lineage OS 14.1 on it but don't use it enough to say if its a problem.
Basically I have no idea where the problem lies as the only common denominator is "new hardware sucks always". Some old hardware sucks. Some LED is ok and some sucks. Some IPS is ok and some sucks. No characteristic, inclucing supposedly "safe" software, is always good or always bad without exception...including CCFL.