So using the manufacturer's icc profile helps to reduce eye strain. This is god to know. But it does not get rid 100% of the eye strain, right? That means there must be something else that is (still) causing us eye strain.
Can u try one more thing? For Monitor driver, try using Generic PnP driver instead of the manufacturer's one. See if that helps. Here's how to do it:
Control Panel -> Device Manager -> Monitor -> select monitor and right click -> Update Driver Software -> Browse my computer for driver software -> Let me pick from a list of device drivers from my computer -> Generic PnP Monitor -> click Next.
When I use the Generic PnP monitor driver on my laptop, I do noticed a very noticeable relief in eye strain. It's like the eye strain is significantly reduced. When I switch the monitor driver back to the Lenovo's driver, I definitely feel the eye strain more. When I switch back to the Generic PnP monitor driver, noticeably less eye strain. Can you give it a try and see if it has any effect on your eye strain or not?