Hi guys! I've been experiencing the same problem as you for last 3 yrs, but today I came up with some other solution.
I have RTX 2060 and especially during gaming, I couldn't play for longer than 30 mins. After that time, my eyes become red, I got headache and things like that. And it was very extreme, I mean the eye strain was killing me and all I had in my mind then to just close them for an hour and take some rest. My gf and friend felt similar, when we were playing some local coop games.
I've been trying everything from software point of view - drivers reinstalls, old drivers, low details, adjust Nvidia Control Panel and so on. Literally everything I could find on the net.
Today I decided to try playing games on linux-based OS. So I installed Linux mint on second disk since I have experience with this OS already, and then installed necessary software on it, like Steam, GPU drivers, and other helpful stuff.
And I gotta say that the difference is huge, in a positive way. First thing I noticed, that even web-browsing was nicer today, because on windows I could feel some strain after an hour (no that big as during gaming, but still), on mint I can surf for much longer. But coming back to gaming, I was be playing The Witcher 3 for about 2 hrs and then I didn't feel any strain or headache at all. So it seems that the driver on windows is not working in the best way, at least in my case, since I couldn't play for even an hour without any problems.
And I know and understand that linux-based os might be hard for some, since it's not as user-friendly as windows, but if you are able to easily go deeper into your windows machines with drivers, overclocking and stuff like that, I would suggest give linux a shot. I mean, it's not that hard to use today. When it comes to gaming, most titles are there (like the witcher, for instance), but some of them are not (like fifa 21 in my case, it's possible to run it but it doesn't work that good, since it's not supported really well I would say, to keep it simple).
Today many things are moved towards web-browsers and web apps, so it's really easier than it was 5-10 yrs ago or even 3 yrs ago (I was using linux then, and I can see the progress it's made).