hansennnnn The twilight app gives a soft red tint to the screen to help filter out "Blue Light" that can cause issues when its night.
The Motorola Edge 30 Neo has built in Colour Saturation….

When I look at a screen my issues start within 2 or 3 seconds, so quickly. The symptoms I have experienced include tiredness, nausea and pain. Each screen is different and the strength of symptoms vary. I have never experienced migraine or headache from a screen only pain / soreness around the eyes and tightness around the forehead at worst.
My symptoms are always around the eyes and forehead not at the side or back. Reading the comments on this forum I am lucky not to experience as strong symptoms as many others do.
In addition to the symptoms when looking at the screen it is also about how long my eyes take to return to normal. I tried a screen many years ago and my eyes didn't feel better until the next day after sleeping.
So when trying a new screen it is about the symptoms when looking at the screen and also how long they last for once I have stopped looking and my eyes return to normal.
So for me yes, it is about can my eyes adapt to the screen.
Over the first few days or week of owning a new screen I think about the symptoms and make a decision on whether I believe I can use the screen long term without serious issue and whether I believe my eyes will adapt.
My Google Pixel 3a took maybe 3 months or so to adapt. So far I have had the Motorola Edge 30 Neo for 5 months and my eyes are adapting slowly however I am unsure if it will be as good as the Pixel. Still I am happy enough to use the handset on a daily basis as the symptoms are mild.
Some mobiles that I have tried previously have been returned only a day or two after first using as the eye issues are so strong.
For example I bought an iphone XR which caused strong nausea and soreness so I knew I could not tolerate this long term.
Interestingly I tried an iphone 12 not long after and the symptoms were mild, not too different to the Motorola Edge 30 Neo.