Sentiny I also noticed that changing any setting related to GPU (especially not default MacOS settings) , such as Reduced Motion, Reduced Transparency, Display Contrast or even enabling/disabling "Scroll & Zoom" settings in trackpad options (smart zoom, rotation, zoom in or out) somehow influence on text clarity and eye fatigue for me.
Had the same feel. I mostly credited it to breaking habitation in the brain. It can also work the other way around where doing some more significant changes forces something to actually do it's job with filtering. For example having reflections or shining a light on the screen makes it better for me, as the brain has no other option than filtering out things.
But, seeing this I'm not sure anymore. I found that certain things can cause software rendering of the cursor, that causes dithering in a rather large area around it. For example using color tables.
I've always felt that tweaking will just make everything glow again, but as I said earlier in the thread it is hard to know if it is neurological or if it is the panel, as it is transient. What if changing things clears some cache or that some already checked value used for dithering adjustments doesn't get updated, or even causes some timing mismatch. In which case it should at least disappear after powering down the machine (and gpu), and giving it a few min to cache, heat up or whatever.
It would be interested if someone could measure before and after some of these changes, or even diff the ioreg. Or just try to induce it and see if recoding works without changing everything back.